药品详情：
【盐酸丙咪嗪Tofranil 简述】
盐酸丙咪嗪Tofranil又名丙咪嗪、 米帕明，是一类抗抑郁药品。
【盐酸丙咪嗪Tofranil 适应症】
本品适用于治疗迟缓性的内因性抑郁症，反应性抑郁症及更年期抑郁症。还可用于儿童遗尿症。镇静作用和抗胆碱均属中等。
【盐酸丙咪嗪Tofranil 规格】
本品为片剂，每片含有效成份10mg/25mg，每瓶30片装。
【盐酸丙咪嗪Tofranil 服用方法】
（1）成人常用量：口服，开始一次25～50mg，每日2～4次，以后渐增至每日总量100～300mg。老年病人每日总量30～40mg，分次服用。须根据耐受情况而调整用量。
（2）小儿常用量：口服，治疗6岁以上儿童的遗尿症，每日1次，睡前1小时服25mg。如在一周内未获满意效果，12岁以下每日可增至50mg，12岁以上每日可增至75mg。每日量超过75mg并不能提高治疗遗尿症的效果。
【盐酸丙咪嗪Tofranil 不良反应】
常见震颤，头晕，失眠，口干、心动过速、视力模糊、眩晕，有时出现定向障碍，记忆障碍，便秘、失眠、胃肠道反应、荨麻疹、心肌损害、直立性低血压，偶见白细胞减少。服药期间忌用升压药。高血压、动脉硬化、青光眼患者慎用。癫痫病人及孕妇忌用。用量较大及长期用药者宜作白细胞计数及肝功能检查。
Tofranil(Imipramine)
Imipramine, sold under the brand name Tofranil among others, is a tricyclic antidepressant (TCA) which is used mainly in the treatment of depression. It can also reduce symptoms of agitation and anxiety. The drug is also used to treat bedwetting. It is taken by mouth. A long-acting form for injection into muscle is also available.
Common side effects of imipramine include dry mouth, drowsiness, dizziness, low blood pressure, rapid heart rate, urinary retention, and electrocardiogram changes. Overdose can result in death. The drug appears to work by increasing levels of serotonin and norepinephrine and by blocking certain serotonin, adrenergic, histamine, and cholinergicreceptors.
Imipramine was discovered in 1951 and was introduced for medical use in 1957. It was the first TCA to be marketed. Imipramine and the other TCAs have decreased in use in recent decades due to the introduction of the selective serotonin reuptake inhibitors (SSRIs), which have fewer side effects and are safer in overdose.
Medical uses
Imipramine is used in the treatment of depression, such as depression associated with agitation or anxiety. It is similar in efficacy to the antidepressant drug moclobemide.[3] It has also been used to treat nocturnal enuresis because of its ability to shorten the time of delta wave stage sleep, where wetting occurs. In veterinary medicine, imipramine is used with xylazine to induce pharmacologic ejaculation in stallions.
Available forms
Imipramine is available in the form of oral tablets and as a formulation for depotintramuscular injection.
Contraindications
Combining it with alcohol consumption causes excessive drowsiness. It may be unsafe during pregnancy.
注：药品如有新包装,以新包装为准。以上资讯来源于网络或由高等医药院校的学生志愿者翻译（如有错漏，请帮忙指正），仅供医护人员内部讨论，不作任何用药依据，具体用药指引，请咨询主治医师。
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